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Human microbiome and prostate cancer development: current insights into the prevention and treatment

Solmaz Ohadian Moghadam, Seyed Ali Momeni

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 11-32 doi: 10.1007/s11684-019-0731-7

Abstract: The huge communities of microorganisms that symbiotically colonize humans are recognized as significant players in health and disease. The human microbiome may influence prostate cancer development. To date, several studies have focused on the effect of prostate infections as well as the composition of the human microbiome in relation to prostate cancer risk. Current studies suggest that the microbiota of men with prostate cancer significantly differs from that of healthy men, demonstrating that certain bacteria could be associated with cancer development as well as altered responses to treatment. In healthy individuals, the microbiome plays a crucial role in the maintenance of homeostasis of body metabolism. Dysbiosis may contribute to the emergence of health problems, including malignancy through affecting systemic immune responses and creating systemic inflammation, and changing serum hormone levels. In this review, we discuss recent data about how the microbes colonizing different parts of the human body including urinary tract, gastrointestinal tract, oral cavity, and skin might affect the risk of developing prostate cancer. Furthermore, we discuss strategies to target the microbiome for risk assessment, prevention, and treatment of prostate cancer.

Keywords： microbiome     prostate cancer     prevention     treatment     molecular pathological epidemiology (MPE)     biomarker    

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Recent transmission of Mycobacterium tuberculosis in China: the implication of molecular epidemiology

Chongguang Yang, Qian Gao

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 76-83 doi: 10.1007/s11684-017-0609-5

Abstract: Evidence from molecular epidemiology studies has delineated the recent transmission of ( ) strains inWe reviewed the implementations of molecular epidemiology of TB in China, the estimated disease burden

Keywords： tuberculosis     recent transmission     molecular epidemiology     China    

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The epidemiology of norovirus gastroenteritis in China: disease burden and distribution of genotypes

Honglu Zhou, Songmei Wang, Lorenz von Seidlein, Xuanyi Wang

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 1-7 doi: 10.1007/s11684-019-0733-5

Abstract: With the improvements of sanitation and nationwide safe water supply the occurrence of bacterial diarrhea declined remarkably, while viruses became the leading causes of acute gastroenteritis (AGE). Of these viruses, noroviruses (NoVs) are responsible for a considerable burden of gastroenteritis, especially in children<2 years and elderly≥65 years. NoVs circulating in the Chinese population are antigenically highly diverse with the genotype GII.4 being the dominant strain followed by GII.3. Given the widespread contamination in environmental sources, and highly infectious nature of NoVs, vaccination would be the desirable strategy for the control of NoV infections. However, a better understanding of acquired immunity after infection, and a reliable immunological surrogate marker are urgently needed, since two vaccine candidates based on virus-like particles (VLPs) are currently moving into clinical evaluations in China.

Keywords： molecular epidemiology     norovirus     disease burden     genotype     China    

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Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic

Frontiers of Medicine doi: 10.1007/s11684-023-1050-6

Abstract: This review endeavors to furnish a holistic insight into pancreatic cancer, encompassing its epidemiologypredisposition and environmental exposures, and explore recent research advancements in precursor lesions and molecular

Keywords： pancreatic cancer     cancer screening     single cell     molecular alterations     precancerous lesion     therapy    

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Neosporosis: An Overview of Its Molecular Epidemiology and Pathogenesis Review

Asis Khan, Jahangheer S. Shaik, Patricia Sikorski, Jitender P. Dubey, Michael E. Grigg

Engineering 2020, Volume 6, Issue 1,   Pages 10-19 doi: 10.1016/j.eng.2019.02.010

Abstract: Although molecular epidemiology studies are in their infancy, the 18S rRNA and ITS1 regions within theThe aim of this review is to outline our current understanding of the molecular epidemiology and genomics

Keywords： Neosporosis     Molecular epidemiology     Population genetics     Genomics     Host response     Vaccine    

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Molecular epidemiology of Cryptococcus neoformans species complex isolates from HIV-positive and HIV-negative

Min CHEN MM, Wei-Hua PAN MD, Wan-Qing LIAO MM, Xiao-Ran LI BS, Bi-Wei FENG BS, Zhe-Xue QUAN PhD, Shao-Xi WU MD, Xiao-Ping TANG MD, Zhi-Rong YAO MD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 117-126 doi: 10.1007/s11684-010-0011-z

Abstract: This study investigated the molecular types of the species complex isolates and their clinical manifestationsThe molecular types of 109 isolates from 108 patients were analyzed by the PCR fingerprinting method,In HIV-positive patients, clinical isolates were grouped into molecular types VNI (75%, 15/20), VNIIIn HIV-negative patients, the majority of the clinical isolates were grouped into molecular types VNIAs for the clinical manifestations of the molecular types among the patients, the average cerebrospinal

Keywords： Cryptococcus neoformans     Cryptococcus gattii     cryptococcosis     molecular epidemiology     molecular type     mating    

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Observations on pathological and histochemical changes in piglet livers infected with Taenia saginata

LINGHU Yan, ZHU Wujun, BAO Huai′en, CHEN Yan

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 258-263 doi: 10.1007/s11684-007-0049-8

Abstract: To study the pathological and histochemical characteristics of lesions in piglet livers infected withThe pathological changes in the piglet livers were observed after the infection using liver sectionsconcluded that pigs are the favorable intermediate host of and its infection can result in serious pathological

Keywords： hydropic degeneration     significant difference     -exposed     favorable intermediate     different    

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Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China

Rui Yu,Rong Fan,Jinlin Hou

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 135-144 doi: 10.1007/s11684-014-0331-5

Abstract: The universal vaccination program since 1992 has changed the epidemiology of hepatitis B virus infection

Keywords： chronic hepatitis B     epidemiology     prevention     treatment    

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Imaging technologies for plant high-throughput phenotyping: a review

Yong ZHANG, Naiqian ZHANG

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 4,   Pages 406-419 doi: 10.15302/J-FASE-2018242

Abstract: applications of these technologies in detecting and measuring plant morphological, physiological, and pathological

Keywords： high-throughput phenotyping     imaging technology     morphological traits     pathological traits     physiological    

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Molecular Epidemiology of Klebsiella pneumoniae from Clinical Bovine Mastitis in Northern Area Article

Shikai Song, Wenjuan He, Dawei Yang, Manar Benmouffok, Yao Wang, Jiyun Li, Chengtao Sun, Xiangbin Song, Shizhen Ma, Chang Cai, Shuangyang Ding, Congming Wu, Zhangqi Shen, Yang Wang,

Engineering 2022, Volume 10, Issue 3,   Pages 146-154 doi: 10.1016/j.eng.2021.01.015

Abstract: However, data is lacking on the molecular characteristics of bovine K. pneumoniae, limiting

Keywords： Clinical mastitis     Klebsiella pneumonia     Molecular characteristics     Population structure     Antimicrobial    

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Epidemiology of fungal infections in China

Min Chen, Yuan Xu, Nan Hong, Yali Yang, Wenzhi Lei, Lin Du, Jingjun Zhao, Xia Lei, Lin Xiong, Langqi Cai, Hui Xu, Weihua Pan, Wanqing Liao

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 58-75 doi: 10.1007/s11684-017-0601-0

Abstract:

With the increasing number of immunocompromised hosts, the epidemiological characteristics of fungal infections have undergone enormous changes worldwide, including in China. In this paper, we reviewed the existing data on mycosis across China to summarize available epidemiological profiles. We found that the general incidence of superficial fungal infections in China has been stable, but the incidence of tinea capitis has decreased and the transmission route has changed. By contrast, the overall incidence of invasive fungal infections has continued to rise. The occurrence of candidemia caused by species other than and including some uncommon species has increased recently in China. Infections caused by have also propagated in recent years, particularly with the emergence of azole-resistant . An increasing trend of cryptococcosis has been noted in China, with var. ST 5 genotype isolates as the predominant pathogen. Retrospective studies have suggested that the epidemiological characteristics of pneumonia in China may be similar to those in other developing countries. Endemic fungal infections, such as sporotrichosis in Northeastern China, must arouse research, diagnostic, and treatment vigilance. Currently, the epidemiological data on mycosis in China are variable and fragmentary. Thus, a nationwide epidemiological research on fungal infections in China is an important need for improving the country’s health.

Keywords： fungi     infection     epidemiology     China    

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Special issue on “Molecular Sensors and Molecular Logic Gates”

Luling Wu , Tony D. James

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 1-3 doi: 10.1007/s11705-021-2134-y

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Explanation of Pathological Changes of Five Zang Organs in Wuxingshengke

吉良展,陈光曼

Strategic Study of CAE 2006, Volume 8, Issue 4,   Pages 94-94

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Design of bio-oil additives via molecular signature descriptors using a multi-stage computer-aided molecular

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 2,   Pages 168-182 doi: 10.1007/s11705-021-2056-8

Abstract: In this work, computer-aided molecular design tools were developed to design optimal solvents to upgradeAs different property prediction models consist different levels of structural information, molecularDue to the combinatorial nature of higher-order signatures, the complexity of a computer-aided molecular

Keywords： computer-aided molecular design     bio-oil additives     molecular signature descriptor    

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Progress on molecular biomarkers and classification of malignant gliomas

Chuanbao Zhang, Zhaoshi Bao, Wei Zhang, Tao Jiang

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 150-156 doi: 10.1007/s11684-013-0267-1

Abstract: Great efforts have been made to incorporate new information about the molecular landscape of gliomas

Keywords： malignant glioma     molecular biomarker     IDH1     MGMT     molecular classification    

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Title Author Date Type Operation

Human microbiome and prostate cancer development: current insights into the prevention and treatment

Solmaz Ohadian Moghadam, Seyed Ali Momeni

Journal Article

Recent transmission of Mycobacterium tuberculosis in China: the implication of molecular epidemiology

Chongguang Yang, Qian Gao

Journal Article

The epidemiology of norovirus gastroenteritis in China: disease burden and distribution of genotypes

Honglu Zhou, Songmei Wang, Lorenz von Seidlein, Xuanyi Wang

Journal Article

Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic

Journal Article

Neosporosis: An Overview of Its Molecular Epidemiology and Pathogenesis

Asis Khan, Jahangheer S. Shaik, Patricia Sikorski, Jitender P. Dubey, Michael E. Grigg

Journal Article

Molecular epidemiology of Cryptococcus neoformans species complex isolates from HIV-positive and HIV-negative

Min CHEN MM, Wei-Hua PAN MD, Wan-Qing LIAO MM, Xiao-Ran LI BS, Bi-Wei FENG BS, Zhe-Xue QUAN PhD, Shao-Xi WU MD, Xiao-Ping TANG MD, Zhi-Rong YAO MD,

Journal Article

Observations on pathological and histochemical changes in piglet livers infected with Taenia saginata

LINGHU Yan, ZHU Wujun, BAO Huai′en, CHEN Yan

Journal Article

Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China

Rui Yu,Rong Fan,Jinlin Hou

Journal Article

Imaging technologies for plant high-throughput phenotyping: a review

Yong ZHANG, Naiqian ZHANG

Journal Article

Molecular Epidemiology of Klebsiella pneumoniae from Clinical Bovine Mastitis in Northern Area

Shikai Song, Wenjuan He, Dawei Yang, Manar Benmouffok, Yao Wang, Jiyun Li, Chengtao Sun, Xiangbin Song, Shizhen Ma, Chang Cai, Shuangyang Ding, Congming Wu, Zhangqi Shen, Yang Wang,

Journal Article

Epidemiology of fungal infections in China

Min Chen, Yuan Xu, Nan Hong, Yali Yang, Wenzhi Lei, Lin Du, Jingjun Zhao, Xia Lei, Lin Xiong, Langqi Cai, Hui Xu, Weihua Pan, Wanqing Liao

Journal Article

Special issue on “Molecular Sensors and Molecular Logic Gates”

Luling Wu , Tony D. James

Journal Article

Explanation of Pathological Changes of Five Zang Organs in Wuxingshengke

吉良展,陈光曼

Journal Article

Design of bio-oil additives via molecular signature descriptors using a multi-stage computer-aided molecular

Journal Article

Progress on molecular biomarkers and classification of malignant gliomas

Chuanbao Zhang, Zhaoshi Bao, Wei Zhang, Tao Jiang

Journal Article